Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atorvastatin hemicalcium salt (Atorvastatin Calcium) 是一种口服有效的 HMG-CoA 还原酶抑制剂 ,可用作降低胆固醇的药物。它抑制人 SV-SMC 增殖和侵袭,IC50分别为 0.39 μM 和 2.39 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 297 | 现货 | ||
25 mg | ¥ 463 | 现货 | ||
50 mg | ¥ 587 | 现货 | ||
100 mg | ¥ 878 | 现货 | ||
200 mg | ¥ 1,380 | 现货 | ||
500 mg | ¥ 2,953 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 344 | 现货 |
产品描述 | Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. |
靶点活性 | HMG-CoA reductase:8 nM |
体外活性 | 在statin处理过的大鼠中,Atorvastatin降低p22phox和NOX1血管mRNA的表达,同时提高主动脉过氧化氢酶的表达.在胆固醇喂养的兔子中,Atorvastatin抑制C反应蛋白的血清水平的增加. |
体内活性 | 在血管平滑肌细胞中, Atorvastatin(0.1 μM)能够抑制血管紧张素Ⅱ和肿瘤坏死因子-α诱导的NF-κB活化;Atorvastatin(1 μM)减少血管紧张素Ⅱ和肿瘤坏死因子-α诱导的IP-10的表达。 |
细胞实验 | Briefly, SV-SMC from 5 different patients are seeded into 24-well cell culture plates at a density of 1×104?cells per well in full growth medium. Cells are incubated overnight and then quiesced in serum free medium for 3 days before transfer to full growth medium (10% FCS) containing 5 different statins (simvastatin, atorvastatin, fluvastatin, lovastatin, and pravastatin)at a range of concentrations. All statins are tested on cells from each individual patient. Medium and drugs are replaced after 2 days, and viable cell numbers are determined in triplicate wells after 4 days using Trypan Blue and a hemocytometer. The increase in cell number is calculated by subtracting the starting cell number (day 0) from the final cell number (day 4). Data are then normalized to control values (no statin) to correct for differences in proliferation rates between cells from different patients. |
别名 | Lipitor, Atorvastatin hemicalcium, Atorvastatin Calcium, CI-981, 阿托伐他汀钙, Sortis |
分子量 | 577.67 |
分子式 | C33H34FN2O5·1/2Ca |
CAS No. | 134523-03-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (43.28 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7311 mL | 8.6555 mL | 17.3109 mL | 43.2773 mL |
5 mM | 0.3462 mL | 1.7311 mL | 3.4622 mL | 8.6555 mL | |
10 mM | 0.1731 mL | 0.8655 mL | 1.7311 mL | 4.3277 mL | |
20 mM | 0.0866 mL | 0.4328 mL | 0.8655 mL | 2.1639 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Atorvastatin hemicalcium salt 134523-03-8 Apoptosis Autophagy Metabolism Ferroptosis HMG-CoA Reductase inhibit Lipitor Inhibitor Atorvastatin Atorvastatin hemicalcium Atorvastatin Calcium HMG-CoA Reductase (HMGCR) CI-981 阿托伐他汀钙 CI 981 CI981 Sortis inhibitor